Miller Lab Alumnus Andreas Nieder tells you everything you need to know about the brain substrates of the sense of number:

Nieder, Andreas. “The neuronal code for number.” Nature Reviews Neuroscience (2016).

 

 

Nice review of past work on the neurobiology of working memory and capacity limits:

Constantinidis, Christos, and Torkel Klingberg. “The neuroscience of working memory capacity and training.” Nature Reviews Neuroscience (2016).

Although there is a caveat:  More recent work suggests that the substrate of working memory is *not* sustained spiking activity.  That is an artifact of cross-trial averaging.  “Delay activity” is more sparse and bursty on single trials.  This suggests a different memory substrate.

See:

Lunqvist, M., Rose, J., Herman, P, Brincat, S.L, Buschman, T.J., and Miller, E.K. (2016) Gamma and beta bursts underlie working memory.  Neuron, published online March 17, 2016. View PDF

Stokes, Mark G. “‘Activity-silent’working memory in prefrontal cortex: a dynamic coding framework.” Trends in cognitive sciences 19.7 (2015): 394-405.

Stokes and Spaak review our recent work on single-trial analysis of working memory “delay” activity.   This showed that the classic profile of sustained activity as the memory substrate is an artifact of averaging across trials.  The assumption is that averaging cancels out noise.  Instead, it may be covering up important details of the dynamics of neural activity.

Read more here:
The Importance of Single-Trial Analyses in Cognitive Neuroscience
Mark Stokes and Eelke Spaak
Trends in Cognitive Sciences
DOI: http://dx.doi.org/10.1016/j.tics.2016.05.008

The original paper:
Lunqvist, M., Rose, J., Herman, P, Brincat, S.L, Buschman, T.J., and Miller, E.K. (2016) Gamma and beta bursts underlie working memory.  Neuron, published online March 17, 2016. View PDF »

A wonderful tribute to a dear friend

Suzanne Corkin, Who Helped Pinpoint Nature of Memory, Dies at 79

 

Nice paper showing that different task demands in different task stages engage different oscillatory bands in the prefrontal cortex.

Wimmer, Klaus, et al. “Transitions between Multiband Oscillatory Patterns Characterize Memory-Guided Perceptual Decisions in Prefrontal Circuits.”The Journal of Neuroscience 36.2 (2016): 489-505.

ekmillerlab.mit.edu

That is all

Despite Bans, Many Still Text While Driving.  Radio Boston WBUR 90.0 FM
Listen here

Earl Miller receives the Kent State University Professional Achievement Award from KSU President Beverly Warren.

And delivers the Commencement Address:

 

Free access to our new paper:
Lundqvist, M., Rose, J., Herman, P., Brincat, S. L., Buschman, T. J., & Miller, E. K. (2016). Gamma and Beta Bursts Underlie Working Memory. Neuron.

Valid until May 26, 2016

Tsutsui et al shows how the prefrontal cortex integrates rule and category information for a behavioral decision.

Tsutsui, Ken-Ichiro, et al. “Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection.” The Journal of Neuroscience 36.10 (2016): 3038-3048.