A trial by trial analysis showed that beta bursts, as opposed to power averaged across trials, is a good predictor of variations in motor behavior.
Torrecillos, F., Tinkhauser, G., Fischer, P., Green, A. L., Aziz, T. Z., Foltynie, T., … & Tan, H. (2018). Modulation of beta bursts in the subthalamic nucleus predicts motor performance. Journal of Neuroscience, 38(41), 8905-8917.
Rodu, J., Klein, N., Brincat, S. L., Miller, E. K., & Kass, R. E. (2018). Detecting Multivariate Cross-Correlation Between Brain Regions. Journal of neurophysiology.
The problem of identifying functional connectivity from multiple time series data recorded in each of two or more brain areas arises in many neuroscientific investigations. For a single stationary time series in each of two brain areas statistical tools such as cross-correlation and Granger causality may be applied. On the other hand, to examine multivariate interactions at a single time point, canonical correlation, which finds the linear combinations of signals that maximize the correlation, may be used. We report here a new method that produces interpretations much like these standard techniques and, in addition, 1) extends the idea of canonical correlation to 3-way arrays (with dimensionality number of signals by number of time points by number of trials), 2) allows for nonstationarity, 3) also allows for nonlinearity, 4) scales well as the number of signals increases, and 5) captures predictive relationships, as is done with Granger causality. We demonstrate the effectiveness of the method through simulation studies and illustrate by analyzing local field potentials recorded from a behaving primate.
When MIT neuroscientist Earl Miller was in graduate school at Princeton, he was inspired by the lectures of George A. Miller, an influential psychologist who helped to spark the young student’s interest in working memory. Now, as the newly named 2019 recipient of the George A. Miller Prize in Cognitive Neuroscience, Earl Miller is set to deliver a lecture honoring his teacher at the annual meeting of the Cognitive Neuroscience Society in San Francisco in March.
Read more here.
Nice review from Miler Lab alumnus Joni Wallis arguing for the importance of single-trial analyses. Variability across trials may not be noise, it may be cognition. Joni argues that ensembles, not single neurons, are the fundamental unit in the brain. One needs to record from many neurons simultaneously to understand cognitive processes.
Wallis, J. D. (2018). Decoding Cognitive Processes from Neural Ensembles. Trends in Cognitive Sciences.
This review highlights work showing that spectrally distributed oscillations and their coupling have functional relevance for sensorimotor processing.
Palva, S., & Palva, J. M. (2018). Roles of brain criticality and multiscale oscillations in temporal predictions for sensorimotor processing. Trends in Neurosciences, 41(10), 729-743.
Nice FMRI study showing that working memory delay activity is primarily in the superficial, feedforward, cortical layers while behavioral response-related activity is primarily in deep, feedback layers.
Layer-dependent activity in human prefrontal cortex during working memory
Emily S. Finn, Laurentius Huber, David C. Jangraw, Peter A. Bandettini
This is very consistent with our recent work:
Bastos, A.M., Loonis, R., Kornblith, S., Lundqvist, M., and Miller, E.K. (2018) Laminar recordings in frontal cortex suggest distinct layers for maintenance and control of working memory. Proceedings of the National Academy of Sciences. View PDF
Holmes, C.D., Papadimitriou, C., Snyder, L.H.(2018) Dissociation of LFP Power and Tuning in the Frontal Cortex during Memory Journal of Neuroscience
Nice paper. Well done. But with a caveat. The authors show that absolute power is dissociated from neural tuning in spiking activity. From this, they conclude that “oscillatory activity by itself is likely not a substrate of memory” and “may be an epiphenomenon of a rate code in the circuit, rather than a direct substrate”.
Not quite. No one is claiming that absolute power alone carries specific information. Rather, it is *patterns of coherence* that carry information (e.g., Buschman et al., 2012; Salazar et al 2012; Antzoulatos and Miller, 2014). If so, there is no reason to think that information would be carried by absolute power. For example, two different patterns of coherence for two different items could have equal global power because it is the pattern, not the global power, that matters. In fact, we and others have shown that coherence and power can be dissociated (Buschman et al., 2012). Using absolute power as a proxy to argue against a functional role for oscillations is a “straw man” argument. It tests a hypothesis that does not reflect the state-of-the-art of thinking on this matter.
Antzoulatos, E.G. and Miller, E.K. (2014) Increases in functional connectivity between the prefrontal cortex and striatum during category learning. Neuron, 83:216-225. View PDF »
Buschman, T.J., Denovellis, E.L., Diogo, C., Bullock, D. and Miller, E.K. (2012) Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron. 76: 838-846. View PDF »
Salazar, R.F., Dotson, N.M., Bressler, S.L., and Gray, C.M. (2012). Content-Specific Fronto-Parietal Synchronization During Visual Working Memory. Science 1224000
Another point: The reason they see “tuning” for contra vs ipsilateral targets in power is not because of stimulus tuning per se, it is because the right vs left visual hemifields are somewhat independent. See:
Buschman,T.J., Siegel, M., Roy, J.E. and Miller, E.K. (2011) Neural substrates of cognitive capacity limitations. Proceedings of the National Academy of Sciences. 108(27):11252-5. View PDF »
Kornblith, S., Buschman, T.J., and Miller, E.K. (2015) Stimulus load and oscillatory activity in higher cortex. Cerebral Cortex. Published online August 18, 2015 doi: 10.1093/cercor/bhv182. View PDF »
On the role of cortex-basal ganglia interactions for category learning: A neuro-computational approach
Francesc Villagrasa, Javier Baladron, Julien Vitay, Henning Schroll, Evan G. Antzoulatos, Earl K. Miller and Fred H. Hamker
Journal of Neuroscience 18 September 2018, 0874-18; DOI: https://doi.org/10.1523/JNEUROSCI.0874-18.2018
In addition to the prefrontal cortex (PFC), the basal ganglia (BG) have been increasingly often reported to play a fundamental role in category learning, but the systems-level circuits of how both interact remain to be explored. We developed a novel neuro-computational model of category learning that particularly addresses the BG-PFC interplay. We propose that the BG bias PFC activity by removing the inhibition of cortico-thalamo-cortical loop and thereby provide a teaching signal to guide the acquisition of category representations in the cortico-cortical associations to the PFC. Our model replicates key behavioral and physiological data of macaque monkey learning a prototype distortion task from Antzoulatos and Miller (2011). Our simulations allowed us to gain a deeper insight into the observed drop of category selectivity in striatal neurons seen in the experimental data and in the model. The simulation results and a new analysis of the experimental data, based on the model’s predictions, show that the drop in category selectivity of the striatum emerges as the variability of responses in the striatum rises when confronting the BG with an increasingly larger number of stimuli to be classified. The neuro-computational model therefore provides new testable insights of systems-level brain circuits involved in category learning which may also be generalized to better understand other cortico-basal ganglia-cortical loops
Nice study showing that anterior parts of the prefrontal cortex and more plastic than posterior parts.
Anterior-posterior gradient of plasticity in primate prefrontal cortex
Mitchell R. Riley, Xue-Lian Qi, Xin Zhou & Christos Constantinidis
Nature Communications volume 9, Article number: 3790 (2018)
Zanos et al show that beta oscillations play a role in short-term synaptic plasticity in primate neocortex that may explain the role of oscillations in attention, learning, and cortical reorganization.
Zanos, S., Rembado, I., Chen, D., & Fetz, E. E. (2018). Phase-locked stimulation during cortical beta oscillations produces bidirectional synaptic plasticity in awake monkeys. Current Biology.
See discussion of this paper by Womelsdorf and Hoffman:
Latent Connectivity: Neuronal Oscillations Can Be Leveraged for Transient Plasticity