The Miller Lab

11

Jul 2016

Coding of Visual, Auditory, Rule, and Response Information in the Brain: 10 Years of Multivoxel Pattern Analysis

Miller Lab

Neuroscience

Woolgar et al provide a meta-analysis of experiments using multivoxel pattern analysis in FMRI. They show that cortical areas traditionally though to be visual, auditory or motor, primarily (though not exclusively) code visual, auditory, and motor information. However, the frontoparietal cortex is hypothesized to a multiple-demand network and it shows domain generality, coding multisensory and rule information.

Woolgar, Alexandra, Jade Jackson, and John Duncan. “Coding of visual, auditory, rule, and response information in the brain: 10 years of multivoxel pattern analysis.” Journal of cognitive neuroscience (2016).
24

Mar 2016

Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection

Miller Lab

Neuroscience

Tsutsui et al shows how the prefrontal cortex integrates rule and category information for a behavioral decision.

Tsutsui, Ken-Ichiro, et al. “Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection.” The Journal of Neuroscience 36.10 (2016): 3038-3048.
7

May 2013

Cerebellum and Cognition: Evidence for the Encoding of Higher Order Rules

Miller Lab

Miller Laboratory, Neuroscience, Publications

This paper reports FMRI in humans performing a task requiring first-order rules (S-R associations with a specific motor output) and second order rules that govern the use of the first-order rules. Cerebellum lobules that project to the prefrontal cortex show activation for both types of rules. This suggests that the cerebellum contributes to rule-based behaviors even when the rules are higher-order and don’t directly involve a motor command.
http://cercor.oxfordjournals.org/content/23/6/1433.abstract

For further reading on the role of rules in cognition and their neural implementation see:
Miller, E.K. and Cohen, J.D. (2001) An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24:167-202. View PDF »

Buschman, T.J., Denovellis, E.L., Diogo, C., Bullock, D. and Miller, E.K. (2012) Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron, 76: 838-846. View PDF

Wallis, J.D., Anderson, K.C., and Miller, E.K. (2001) Single neurons in the prefrontal cortex encode abstract rules. Nature, 411:953-956. View PDF »

Coding of Visual, Auditory, Rule, and Response Information in the Brain: 10 Years of Multivoxel Pattern Analysis

Representation of Functional Category in the Monkey Prefrontal Cortex and Its Rule-Dependent Use for Behavioral Selection

Cerebellum and Cognition: Evidence for the Encoding of Higher Order Rules