Soltani et al (2013) explored the role of D1 and D2 dopamine receptors in saccade target selection. They find evidence that D1 receptors modulate the strength of inputs to the frontal eye fields and recurrent connectivity whereas D2 may modulate the output of the FEF. This may be because D1 seems to reduce LTP and LTD, which is consistent with observations that D1 receptors contribute to associative learning (Puig and Miller, 2012). Like Puig and Miller (2012), they also found that D1 blockade increases response perseveration.
Puig, M.V. and Miller, E.K. (2012) The role of prefrontal dopamine D1 receptors in the neural mechanisms of associative learning. Neuron. 74: 874-886. View PDF »
About the Author
The Miller Lab uses experimental and theoretical approaches to study the neural basis of the high-level cognitive functions that underlie complex goal-directed behavior. ekmillerlab.mit.edu