Miller Lab alumnus Andreas Nieder shows that dopamine (DA) has different effects on two different classes of neurons in the prefrontal cortex. For neurons with a short latency visual response, DA suppressed activity but preserved their signal to noise ratio. For neurons with a longer visual latency (exclusively broad-spiking, putative pyramidal neurons), DA increased excitability and enhanced signal/noise ratio. Thus, DA can shape how the prefrontal cortex processes bottom-up sensory inputs.
Jacob et al
About the Author
The Miller Lab uses experimental and theoretical approaches to study the neural basis of the high-level cognitive functions that underlie complex goal-directed behavior. ekmillerlab.mit.edu