Newman et al used the drug scopolamine to disrupt theta-gamma coupling in the medial entorhinal cortex of rats. Gamma power at the peak of theta was reduced and shifted to subsequent phases.  Scopolamine also seemed to reduce the rats’ familiarity with the testing enclosure. The data support the hypothesis that memory encoding and retrieval occur at different theta phases.

About the Author

The Miller Lab uses experimental and theoretical approaches to study the neural basis of the high-level cognitive functions that underlie complex goal-directed behavior.