Zhang et al optogenetically activated the mouse cingulate region and found that it enhanced activity in primary visual cortex (V1), improved visual discrimination and increased center-surround effects. This modulation was mediated by long-range projections that activated GABAergic (inhibitory) circuits in V1. Thus, long-range projection from the frontal lobe may modulate sensory cortex via excitatory action on local inhibitory circuits.
About the Author
The Miller Lab uses experimental and theoretical approaches to study the neural basis of the high-level cognitive functions that underlie complex goal-directed behavior. ekmillerlab.mit.edu