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  • 29
    Jul 2013

    The effects of neural gain on attention and learning


    Miller Lab
    Neuroscience

    Eldar et al show that neural gain influences learning style.  Subjects learned associations between pictures and reward.  The association could be based on different stimulus dimensions and different people had different predispositions for one dimension or the other.  Eldar et al assessed neural gain by pupil dilation (which is correlated with locus coeruleus norepinephrine activity) and found that the higher the gain, the more likely subjects were to follow their predispositions. The increase in gain was thought to boost the asymmetry of strength between different functional networks which are responsible for the predisposition in learning style.

  • 26
    Jul 2013

    A Network for Scene Processing in the Macaque Temporal Lobe


    Miller Lab
    Miller Laboratory, Neuroscience

    Miller Lab graduate student Simon Kornblith publishes a paper in Neuron from work in his old lab.  By combining FMRI with electrode recording and stimulation, they found an area in the occipitotemporal cortex that has many scene-selective neurons, the lateral place patch (LPP).  By stimulating it, they discover connections to several other cortical areas, including a medial place patch (MPP) in the parahippocampal gyrus.  Elegant and important work, Simon, congratulations!  Now, get back to work. ?

  • 26
    Jul 2013

    False memory planted in mouse’s brain


    Miller Lab
    In The News, Neuroscience

    A flurry of articles about Picower Institute’s Susumu Tonegawa’s paper implanting false memories in the mouse brain. They identified and tagged a memory engram for one environment, then activated that engram in a different environment while pairing it with shock.  Later, the animals showed fear in the first environment as if they were shocked there.

    The Guardian

    The New York Times

    The cover of Science

    The paper: Creating a false memory in the hippocampus

  • 25
    Jul 2013

    Pre-registration of scientific papers? Hmmm.


    Miller Lab
    In The News, Neuroscience

    The journal Cortex will peer-review your experimental plan.  If accepted, they agree to publish your results, regardless of how they turn out.  But you must release your raw data so others can have at it.
    Article in the Guardian

  • 25
    Jul 2013

    The Expected Value of Control: An Integrative Theory of Anterior Cingulate Cortex Function


    Miller Lab
    Neuroscience

    Shenhav, Botvinick, and Cohen tie together a number of observations and notions into a new theory of ACC function: allocation of control based on an evaluation of the expected value of control (EVC).

  • 24
    Jul 2013

    Why Public Dissemination of Science Matters: A Manifesto


    Miller Lab
    In The News, Neuroscience, Psychology

    Dave Eagleman spells it out for us.

  • 24
    Jul 2013

    Interesting and provocative: Bottom-up and top-down attention are independent


    Miller Lab
    Psychology

    Pinto et al, despite enough statistical power, fail to see any correlation between performance of a top-down attention task (search) and a bottom-up attention task (singleton capture). They argue that top-down and bottom-up attention systems operate independently.

    They cite our work, which suggests that top-down vs bottom up attention signals originate from prefrontal vs parietal cortex:
    Buschman, T.J. and Miller, E.K. (2007) Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices. Science. 315: 1860-1862  The Scientist’s “Hot Paper” for October 2009. View PDF »

  • 22
    Jul 2013

    Flexible frequency control of cortical oscillations enables computations required for working memory


    Miller Lab
    Neuroscience

    Dipoppa and Gutkin propose a model of working memory in which gamma-beta oscillations gates access, theta oscillations protects working memory from distractions, and alpha oscillations clears out old memories.

    This is consistent with our observations that beta helps from ensembles for rules held in working memory while alpha clears out a dominant ensemble so that a weaker one can be used:
    Buschman, T.J., Denovellis, E.L., Diogo, C., Bullock, D. and Miller, E.K. (2012) Synchronous oscillatory neural ensembles for rules in the prefrontal cortex. Neuron, 76: 838-846.  View PDF

  • 22
    Jul 2013

    The Invisible Gorilla Strikes Again – Sustained Inattentional Blindness in Expert Observers


    Miller Lab
    Psychology

    Radiologists looking for lung nodules miss the a gorilla inserted into the images.  Even experts doing their job are subject to inattentional blindness.
    Drew et al

  • 18
    Jul 2013

    Distinct and Overlapping Frontoparietal Representations of Task Rules


    Miller Lab
    Neuroscience

    Zhang et al studied rule-based behavior by either having human subjects choose the rule themselves or by instructing them to the rule.  They found context-dependent and context-independent (chosen vs instructed)  rule representations in frontal and parietal cortex. This gives insight into the architecture of cognitive control.

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